Volume 3 Number 1 (Jan. 2013)
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IJAPM 2013 Vol.3(1): 59-62 ISSN:2010-362X
DOI: 10.7763/IJAPM.2013.V3.174

Function of the CaMK II on LTP of Exercise Learning

Xiyan Xie, Dan Xu, Shun Li, Yanfen Chen, and Lijuan Hou

Abstract—This Ca2+/calmodulin-dependent kinase II (CaMKII) is an abundant synaptic signaling molecule that is essential for memory formation and the induction of synaptic potentiation. Additionally, CaMKII plays a prominent role in synaptic tagging and metaplasticity. The kinase becomes active in the presence of calcium and has the potential to switch to an autonomous mode of activity upon auto-phosphorylation. Since CaMKII can be autonomously active and required for the formation of memory, CaMKII is central to the mechanism of hippocampal, N-methyl-d-Aspartate NMDA receptor dependent long-term potentiation of synaptic transmission (LTP). However, the exact reason increased activity and how this is worked it is still matter of debate and the exact time window of increased activity and how this is terminated, There is now overwhelming evident that the expression and significance of CaMKII mRNA in hippocampus of rats whose spatial learning and memory function were enhanced by Regular Aerobic Exercise. Thus, regulation of Exercise of the expression of endogenous CaMKII may constitute important role on CaMKII signaling on LTP during memory formation.

Index Terms—Memory, LTP, exercise, camkii.

Lijuan Hou is with Beijing Normal University, majored in exercise physiology, Beijing China. (e-mail: houlj@bnu.edu.cn).

Cite: Xiyan Xie, Dan Xu, Shun Li, Yanfen Chen, and Lijuan Hou, "Function of the CaMK II on LTP of Exercise Learning," International Journal of Applied Physics and Mathematics  vol. 3, no. 1, pp. 59-62, 2013.

General Information

ISSN: 2010-362X
Frequency: Bimonthly (2011-2014); Quarterly (Since 2015)
DOI: 10.17706/IJAPM
Editor-in-Chief: Prof. Haydar Akca
Abstracting/ Indexing: Index Copernicus, EI (INSPEC, IET), Chemical Abstracts Services (CAS), Electronic Journals Library, Engineering & Technology Digital Library, Nanowerk Database, Google Scholar and ProQuest
E-mail: ijapm@iap.org
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